Increased Serum Calcitonin in Sporadic Primary Hyperparathyroidism is an Uncommon Occurrence |
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| Institution: | 1. From the Department of Endocrinology, Diabetes and Metabolism, Santa Croce and Carle Hospital, Cuneo, Italy;2. IRCCS Orthopedic Institute Galeazzi, Endocrinology Service, Milan, Italy;3. Medical Physics Department, Santa Croce and Carle Hospital, Cuneo, Italy.;1. From the Division of Endocrinology, University of Utah, Salt Lake City, Utah;2. Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania;3. Tri Health, Cincinnati, Ohio;4. Division of Ear, Nose, & Throat, University of Utah, Salt Lake City, Utah;5. the Department of Pathology, University of Utah, Salt Lake City, Utah.;1. From George Washington University, Biostatistics Center, Rockville, Maryland;2. University of California San Diego, La Jolla, California;3. National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland;4. National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland;5. University of Wisconsin-Madison, Madison, Wisconsin;6. University of Iowa, Iowa City, Iowa;7. Case Western Reserve University, Cleveland, Ohio;8. Massachusetts General Hospital, Boston, Massachusetts;9. University of Toronto, Toronto, Ontario, Canada;10. University of New Mexico, Albuquerque, New Mexico.;1. From the Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas;2. Department of Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand;3. University of Hawaii Internal Medicine Residency Program, Honolulu, Hawaii;4. Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;5. Department of Endocrinology, Metabolism & Genetics, University of Kansas Medical Center, Kansas City, Kansas;6. Department of Diabetes, Endocrinology & Metabolism, City of Hope National Medical Center, Duarte, California.;1. From the Department of Nuclear Medicine, Peking Union Medical College Hospital, Beijing, China;2. Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China;3. Department of Oncology, the Affiliated Hospital of Qingdao University, Qingdao, China. |
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| Abstract: | Objective: To evaluate calcitonin (CT) levels in sporadic primary hyperparathyroidism (PHPT), which has to date rarely been considered.Methods: We evaluated serum CT levels in 290 consecutive patients with sporadic PHPT at diagnosis.Results: Mild elevations in CT levels (hyperCT) were found in 25 patients (8.6%), with no correlation among the demographic, clinical, and biochemical findings. In addition, no differences were found between patients with and without hyperCT. Follow-up data were available for 19/25 patients, but CT values were only available for 10. CT normalized in all surgically cured patients regardless of the extent of the surgery (parathyroidectomy PTX] only in 8 and associated with partial or total thyroidectomy for benign nodular goiters in 7).Conclusion: hyperCT is an uncommon feature of sporadic PHPT and not related to biochemical or clinical features of the disease. In addition, hyperCT is reversible after PTX, regardless of whether concomitant thyroidectomies have been conducted.Abbreviations: CT = calcitonin; eGFR = estimated glomerular filtration rate; hyperCT = hypercalcitoninemia; MEN = multiple endocrine neoplasm; MTC = medullary thyroid carcinoma; PHPT = primary hyperparathyroidism; PPI = proton pump inhibitor; PTH = parathyroid hormone; PTX = parathyroidectomy |
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