Deep Protein Methylation Profiling by Combined Chemical and Immunoaffinity Approaches Reveals Novel PRMT1 Targets期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Deep Protein Methylation Profiling by Combined Chemical and Immunoaffinity Approaches Reveals Novel PRMT1 Targets

Institution:	3. Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089;4. Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90089;5. Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California 90089;6. Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089

Abstract:	Download : Download high-res image (87KB) Download : Download full-size image Highlights ?Enrichment of methyl peptides using two orthogonal techniques. ?Knockdown of PRMT1 leads to substantial changes in protein arginine “methylome”. ?Discrimination of ADMA and SDMA using characteristic neutral losses. ?Identification of PRMT1 targets and substrate scavenged by other PRMTs in the absence of PRMT1 activity.

Keywords:	Post-translational modifications methylation label-free quantification affinity proteomics immunoaffinity systems biology tandem mass spectrometry arginine lysine strong cation exchange
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