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High-density Peptide Arrays Help to Identify Linear Immunogenic B-cell Epitopes in Individuals Naturally Exposed to Malaria Infection
Affiliation:3. From the 3Center for Infectious Diseases, Parasitology Unit, Heidelberg University Hospital, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany;;4. 4German Center for Infectious Disease Research, Heidelberg (DZIF);;5. 5HEiKA - Heidelberg Karlsruhe Research Partnership, Heidelberg University, Karlsruhe Institute of Technology (KIT), Germany;;6. 6German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany;;12. Centre de Recherche en Santé de Nouna, BP 02 Nouna, Rue Namory Keita, Burkina Faso;;8. 8Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, D 14476 Potsdam, Germany;;9. Department of Oncology and Radiotherapy, M Sklodowska Curie Memorial Cancer Center, Wawelska 15, 02–034 Warsaw, Poland;;10. 10Institute of Microstructure Technology, Karlsruhe Institute of Technology, Germany Hermann-von-Helmholtz-Platz 1, D 76344 Eggenstein-Leopoldshafen, Germany
Abstract:
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  • Highlights
    • •Profiling antibody responses of patients with naturally acquired malaria immunity.
    • •High-density peptide arrays featuring linear epitopes.
    • •Epitope mapping of known and potential novel vaccine candidates.
    • •Novel immunogenic epitopes discovered, and known antibody target motifs confirmed.
    Keywords:Antibodies*  Peptide array  Peptidomics  Malaria  Biomarker: Diagnostic  epitope mapping
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