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Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling
Institution:3. From the 3State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;;4. 4University of Chinese Academy of Sciences, Beijing 100049, China;;5. 5Department of Gastroenterology, The 2nd Affiliated Hospital of Kunming Medical University, Yunnan Research Center for Liver Diseases, Kunming 650033, China;;12. 12Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;;8. 8State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, Jiangsu, China
Abstract:
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  • Highlights
    • ?1. Celastrol alleviated cholestatic liver injury.
    • ?2. Celastrol inhibited the decrease of SIRT1 induced by deoxycholic acid.
    • ?3. SIRT1-FXR signaling pathway mediated the effect of celastrol.
    Keywords:Mass Spectrometry  Mechanism of action  Metabolomics  Hepatotoxicity  Metabolites
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