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Identification of Salivary Biomarkers for Oral Cancer Detection with Untargeted and Targeted Quantitative Proteomics Approaches
Institution:3. 3Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan;4. 4Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan;5. 5Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan;6. 6Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan;12. 12Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan;8. 8Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan;9. 9Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Abstract:
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  • Highlights
    • ?iTRAQ-based analysis of saliva samples from oral cancer patients.
    • ?Proteome profiling of saliva samples from patients with oral premalignant lesions.
    • ?Verification of salivary biomarker candidates with MRM-MS and immunoassays.
    • ?Identification of salivary proteins as potential biomarkers of oral cancer.
    Keywords:iTRAQ  Multiple reaction monitoring  Head and neck cancer  Cancer biomarker(s)  Biomarker: Diagnostic  Biomarker: Prognostic  Oral cavity squamous cell carcinoma  Oral potentially malignant disorder
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