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Proteomic Analysis of Vocal Fold Fibroblasts Exposed to Cigarette Smoke Extract: Exploring the Pathophysiology of Reinke's Edema,
Affiliation:3. 3Division of Phoniatrics, Medical University of Graz, Graz, Austria;4. 4Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria;5. 5Omics Center Graz, BioTechMed-Graz, Graz, Austria;6. 6Austrian Center of Industrial Biotechnology, Graz, Austria;8. 8Takeda, Vienna, Austria
Abstract:
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  • Highlights
    • •First global study on laryngeal cells cultured with cigarette smoke enriched medium.
    • •Vocal fold fibroblasts increased production of ECM component hyaluronan.
    • •Expression of several fibrillar collagens was reduced.
    Keywords:Clinical proteomics  Extracellular matrix*  Inflammation  Oxidative stress  Protein Identification*  Cigarette smoke  Larynx  Reinke's edema  Vocal fold fibroblasts
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