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Integrated Succinylome and Metabolome Profiling Reveals Crucial Role of S-Ribosylhomocysteine Lyase in Quorum Sensing and Metabolism of Aeromonas hydrophila,
Affiliation:3. Fujian Provincial Key Laboratory of Agroecological Processing and Safety Monitoring (School of Life Sciences, Fujian Agriculture and Forestry University), Fuzhou, PR China;;4. Key Laboratory of Crop Ecology and Molecular Physiology (Fujian Agriculture and Forestry University), Fujian Province University, Fuzhou, PR China;;5. Shanghai Key Laboratory of Plant Functional Genomics and Resources, Shanghai Chenshan Plant Science Research Center, Chinese Academy of Sciences, Shanghai Chenshan Botanical Garden, Shanghai, PR China
Abstract:
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  • Highlights
    • •A global lysine succinylome was investigated in A. hydrophila.
    • •The lysine succinylation modifications play crucial role on various metabolic pathways.
    • •Reversible succinylation on Lys23 and Lys30 regulates the activity of S-ribosylhomocysteine lyase LuxS.
    • •Lysine succinylation modifications of LuxS affect quorum sensing and metabolism.
    Keywords:Post-translational Modifications  Affinity Proteomics  Mass Spectrometry  Microbiology  Metabolomics  Activated Methyl Cycle  Quorum Sensing  S-Ribosylhomocysteine Lyase  Succinylome
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