The Association Between Body Mass Index and Subclinical Thyroid Dysfunction in Different Sexes of Chinese |
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| Institution: | 1. From the Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China;2. Senior Lecturer in Statistics, Hull York Medical School, University of Hull, Hull, United Kingdom;3. Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, P.R. China;4. Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, P.R. China;5. Department of Health Management, Tianjin Medical University General Hospital, Tianjin, P.R. China;6. Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, P.R. China;7. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, P.R. China.;1. From Department of Endocrinology, The Fifth People''s Hospital of Shanghai, Fudan University, Shanghai, China;2. Department of Obstetrics, Wujing Hospital, Shanghai, China.;1. From the Dallas Diabetes and Endocrine Center, Dallas, Texas;2. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas;3. Sanofi US, Bridgewater, New Jersey;4. Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.;1. From Department of Endocrine Surgery, Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, Ohio;2. Department of General Surgery, St Vincent''s Hospital Melbourne, Fitzroy, Victoria, Australia;3. Department of Endocrine Surgery, Endocrinology and Metabolism Institute, Banner University Medical Centre, Phoenix, Arizona.;1. From the Division of Endocrinology and Metabolism, Department of Medicine, Taoyuan Branch of Taipei Veterans General Hospital, Taoyuan, Taiwan;2. Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan;3. Yeezen General Hospital, Taoyuan, Taiwan;4. Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan;5. Division of Otology, Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan. |
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| Abstract: | Objective: To study subclinical thyroid dysfunction (SCTD)—subclinical hyperthyroidism and subclinical hypothyroidism—in Chinese patients in relation to body mass index (BMI) and to determine whether a difference between sexes exists.Methods: This cross-sectional study recruited 13,503 healthy participants (8,345 male, 5,158 female) who participated in a health examination. Clinical data, including anthropometric measurements and serum parameters, were collected. The association between SCTD and the BMI of each sex was analyzed separately by stratifying the data by SCTD type and regarding BMI as a categorical or as a continuous variable in different models. The odds ratio of SCTD was calculated from binary logistic regression models.Results: The prevalence of both subclinical hyperthyroidism and subclinical hypothyroidism was significantly lower in males compared to females. For subclinical hypothyroidism, we found no significant association with BMI in females. In males, there was a significant negative relationship between BMI and subclinical hypothyroidism. For subclinical hyperthyroidism, we did not find any significant relationship with BMI in either sex after stratifying the data and treating BMI as a categorical or as a continuous variable.Conclusion: For subclinical hyperthyroidism, no significant effect was found in either sex. For subclinical hypothyroidism, high BMI was associated with lower rates of subclinical hypothyroidism in males, and no significant correlation was found in females. The mechanism of this sex-specific association between BMI and SCTD needs more verification.Abbreviations: ALT = alanine aminotransferase; AST = aspartate aminotransferase; BMI = body mass index; BUN = blood urea nitrogen; CI = confidence interval; Cr = creatinine; DBP = diastolic blood pressure; FG = fasting glucose; FT3 = free triiodothyronine; FT4 = free thyroxine; HDL = high-density lipoprotein; LDL = low-density lipoprotein; OR = odds ratio; SBP = systolic blood pressure; SCTD = subclinical thyroid dysfunction; TBIL = total bilirubin; TC = total cholesterol; TG = triglyceride; TSH = thyroid-stimulating hormone; UA = uric acid; WBC = white blood cell; WC = waist circumference |
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