Decreased Antibiotic Susceptibility Driven by Global Remodeling of the Klebsiella pneumoniae Proteome
Institution:
3. From the 3Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland;;4. Molecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland;;5. Laboratory of Proteomics and Analytical Technologies, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, NCI-Frederick, Frederick, Maryland;;6. Pathology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland
Abstract:
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Highlights
?Global proteomic remodeling alters antibiotic susceptibility in K. pneumoniae.
?Drug specific transport, sugar utilization, central metabolism, capsule synthesis.
?Common pathways of reactive oxygen scavenging, turnover of misfolded proteins.
?Integrated adjustments and unique drug-specific features for drug combinations.
