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Delta-S-Cys-Albumin: A Lab Test that Quantifies Cumulative Exposure of Archived Human Blood Plasma and Serum Samples to Thawed Conditions,
Affiliation:3. School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287;4. Maricopa Integrated Health System, Phoenix, AZ 85008;5. University of Arizona College of Medicine, Phoenix, AZ 85004
Abstract:
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  • Highlights
    • •Endogenous plasma/serum QC marker that quantifies cumulative sample thawed time.
    • •Mechanism of marker change known, and rate law established.
    • •Data interpretation based on documented population averages and rate law.
    • •Blind-challenge verified; utility proven via exposure of undisclosed freezer outage.
    Keywords:Serum/plasma  plasma or serum analysis  biobanking  quality control and metrics  post-translational modifications  cysteine  cystine  quality assurance  s-cysteinylated albumin
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