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Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection
Institution:From the 3Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel;;4Sheba Cancer Research Center, Chaim Sheba Medical Center, Ramat Gan, Israel;;5Division of Gynecologic Oncology, Meir Medical Center, Kfar Saba, Israel;;6Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel;;**Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel;;12Department of Gynecologic Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel;;8The Susanne-Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel;;9Department of Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel;;10Department of Gynecologic Oncology, Rabin Medical Center, Petah Tikva, Israel;;123Department of Obstetrics & Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel;;84Department of Pathology, Chaim Sheba Medical Center, Ramat Gan, Israel;;95The Talpiot Medical Leadership Program, Chaim Sheba Medical Center, Ramat Gan, Israel
Abstract:
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  • Highlights
    • •Microvesicle proteomics of 187 utero-tubal lavage samples for early diagnosis of HGOC.
    • •Machine learning-based classification of a 9-protein signature with high predictive power.
    • •Signature has 70‥ sensitivity and 76.2‥ specificity, predicting stage I lesions.
    Keywords:Biofluids*  Biomarker: Diagnostic  Ovarian cancer  Mass Spectrometry  Cancer biomarker(s)
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