A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155

Institution:	3. Microchemistry, Proteomics and Lipidomics Department, Genentech, South San Francisco, CA;4. Portfolio Management and Operations, Genentech, South San Francisco, CA;5. Cancer Immunology Department, Genentech, South San Francisco, CA;6. BioMolecular Resources, Genentech, South San Francisco, CA;12. 23 & me Therapeutics, South San Francisco, CA;8. Biochemical Cellular Pharmacology, Genentech, South San Francisco, CA

Abstract:	Download : Download high-res image (55KB) Download : Download full-size image Highlights •New platform for high throughput detection of transient interactions between membrane proteins. •IL20RA is a receptor for the orphan checkpoint inhibitor B7-H3. •The natural killer cell protein KIR2DL5A binds the immune receptor PVR. •KIR2DL5 binding to PVR regulates natural killer cell cytotoxicity and inhibits tumor cell killing. •Elucidation of receptor interactomes to gain insights into extracellular protein biology.

Keywords:	assay development automation cancer therapeutics cell-cell interactions protein-protein interactions secretome
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