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Eukaryotic elongation factor 2 kinase confers tolerance to stress conditions in cancer cells
Authors:Hongcheng Zhu  Xi Yang  Jia Liu  Lu Zhou  Chi Zhang  Liping Xu  Qin Qin  Liangliang Zhan  Jing Lu  Hongyan Cheng  Xinchen Sun
Affiliation:.Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China ;.Department of Neurosurgery, Nanjing Drum Tower Hospital and Clinical College of Nanjing Medical University, Nanjing, China ;.Department of General Internal Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Abstract:Eukaryotic elongation factor 2 (eEF2) is a member of the GTP-binding translation elongation factor family that is essential for protein synthesis. eEF2 kinase (eEF2K) is a structurally and functionally unique protein kinase in the calmodulin-mediated signaling pathway. eEF2K phosphorylates eEF2, thereby inhibiting eEF2 function under stressful conditions. eEF2K regulates numerous processes, such as protein synthesis, cell cycle progression, and induction of autophagy and apoptosis in cancer cells. This review will demonstrate the mechanisms underlying eEF2K activity in cancer cells under different stresses, such as nutrient deprivation, hypoxia, and DNA damage via eEF2 regulation. In vivo, in vitro, and clinical studies indicated that eEF2K may be a novel biomarker and therapeutic target for cancer.
Keywords:Eukaryotic elongation factor 2 kinase   eEF2K   eEF2   Cancer   Stress
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