Analysis of Brain and Cerebrospinal Fluid from Mouse Models of the Three Major Forms of Neuronal Ceroid Lipofuscinosis Reveals Changes in the Lysosomal Proteome期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Analysis of Brain and Cerebrospinal Fluid from Mouse Models of the Three Major Forms of Neuronal Ceroid Lipofuscinosis Reveals Changes in the Lysosomal Proteome

Affiliation:	3. Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854;4. Department of Biochemistry and Molecular Biology, Robert-Wood Johnson Medical School, Rutgers Biomedical Health Sciences, Piscataway, NJ 08854;5. Department of Biostatistics, School of Public Health, Rutgers - The State University of New Jersey, Piscataway, NJ 08854

Abstract:	Download : Download high-res image (108KB) Download : Download full-size image Highlights •Proteomic analysis of brain and cerebrospinal fluid from mouse NCL models. •Disease-associated changes in lysosomal proteins and markers of neuroinflammation. •Biomarker candidates identified for further evaluation.

Keywords:	Mouse models biomarker: prognostic cerebrospinal fluid glycoproteins* inflammatory response mass spectrometry neurodegenerative diseases lysosome neuronal ceroid lipofuscinosis
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