PACAP and Other Neuropeptide Targets Link Chronic Migraine and Opioid-induced Hyperalgesia in Mouse Models*
Institution:
3. Department of Chemistry, University of Illinois at Urbana-Champaign, 61801;4. Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 61801;5. Department of Psychiatry, University of Illinois at Chicago, 60612
Abstract:
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Highlights
•Characterized the peptides involved in migraine and opioid-induced hyperalgesia (OIH).
•Identified more than 1500 peptides in seven nervous system regions.
•Discovered seven peptides significantly changed with migraine and nine with OIH.
•Validated PACAP involvement in both conditions via pharmacological studies.
