SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18

Institution:	From the 3School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, IRELAND;;4Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland;;5Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan;;6Maine Medical Center Research Institute, 81 Research Drive, Scarborough, Maine 04074;;**Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

Abstract:	Download : Download high-res image (98KB) Download : Download full-size image Highlights ?Protein interaction screen of SETD1A/COMPASS complex subunits. ?Unexpected interaction with DNA damage protein RAD18 was confirmed for SETD1A, but not for other subunits. ?SETD1A and/or RAD18 influence each other's mRNA and protein expression levels, and disruption of either gene elicits a similar DNA damage sensitivity phenotype.

Keywords:	Protein-Protein Interactions* Methylation* Epigenetics Macromolecular complex analysis Proliferation* DNA damage repair SET/MLL Complex
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