Exposure to the Chinese Famine in Early Life and the Thyroid Function and Nodules in Adulthood |
| |
| Institution: | 1. Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China;2. The Public Health Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.;2. Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai, China;3. Department of Pathology, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, China;4. Department of Neurosurgery, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, China;5. Department of Radiology, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, China.;1. Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;2. Department of Endocrinology, Bishan Hospital of Chongqing, Chongqing, China.;1. Division of Intensive Care Unit, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan;2. Department of Endocrinology, Nippon Medical School Chiba-Hokusoh Hospital, Chiba, Japan;3. Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan |
| |
| Abstract: | Objective: Previous studies found that exposure to famine was associated with a higher risk of metabolic syndrome and fatty liver in adult women. In the present study, we investigated the relationship between exposure to the Chinese famine in early life and thyroid function and nodules in adulthood.Methods: We retrospectively analyzed the data of subjects who underwent routine physical check-up in the Public Health Center of our hospital in 2017. Subjects were divided into 3 groups: post-, pre-, and nonexposed groups. The basal metabolic rate (BMR) was estimated by the revised Harris-Benedict formulation. The serum levels of thyroid hormones were detected. Thyroid ultrasonography was performed by experienced technicians. The diagnosis of thyroid nodules was according to the Thyroid Imaging Reporting and Data System (TI-RADS).Results: Compared to nonexposed subjects, the postnatally exposed subjects had a significantly lower level of thyroxine, and statistically higher ultrasensitive thyroid stimulating hormone (P<.05). There was no significant difference in thyroid autoimmune antibodies between groups exposed to the famine and the nonexposed group (P>.05). There were no statistical differences in heart rate and BMR among these groups (P>.05). Exposure to the famine did not affect either the numbers of thyroid nodules, the TI-RADS score of thyroid nodules, or the maximal diameters of thyroid nodules.Conclusion: Our results indicate a significant association between famine exposure in early life and down-regulated thyroid function in adulthood. Postnatal famine exposure may be more vulnerable to nutrient deficiency and lead to restricted thyroid development in later life.Abbreviations: BMR = basal metabolic rate; FT3 = free triiodothyronine; FT4 = free thyroxine; IDD = iodine deficiency disorder; T3 = triiodothyronine; T4 = thyroxine; TG-Ab = thyroglobulin antibody; TI-RADS = Thyroid Imaging Reporting and Data System; uTSH = ultrasensitive thyroid stimulating hormone |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
