Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts

Institution:	From the 3The Department of Biosciences, Durham University, Stockton Road, Durham, DH1 3LE, UK;;4The Procter & Gamble Company, 8700 Mason Montgomery Road, Mason, OH 45040

Abstract:	Download : Download high-res image (72KB) Download : Download full-size image Highlights ?Changes to the proteome of skin fibroblasts subjected to reductive stress have been quantitated. ?Only a small set of proteins is selectively diminished upon exposure to reductants. ?Collagens (COL1A2 and COL6A2) emerge as sentinels of reductive stress. ?Reductive stress triggers receptor-independent Akt phosphorylation at Ser473.

Keywords:	SWATH-MS Chaperone* Disulfides* Extracellular matrix* Thiol redox chemistry Oxidative stress Label-free quantification Signal Transduction* Aging protein homeostasis skin fibroblasts
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