Prevalence of Obstructive Sleep Apnea Determined by the Watchpat in Nonobese Japanese Patients with Poor Glucose Control And Type 2 Diabetes |
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| Institution: | 1. Department of Endocrinology and Diabetes, Yokohama City University School of Medicine, Yokohama, Japan.;2. Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Japan.;3. Department of Endocrinology and Metabolism, Yokohama City University School of Medicine, Yokohama, Japan.;1. From the Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India;2. Bone & Mineral Research Laboratory, Henry Ford Health System, Detroit, Michigan;3. Department of Orthopedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
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| Abstract: | Objective: Diagnosing obstructive sleep apnea (OSA) usually involves high cost, patient inconvenience, and the need for examination at a specialized center. This study employed a portable, wearable, diagnostic device (WatchPAT) to investigate the prevalence of OSA in nonobese Japanese patients with type 2 diabetes.Methods: Patients with type 2 diabetes were tested for OSA over one night using the WatchPAT. Logistic regression analysis was used to estimate the odds ratios (ORs) of risk factors for OSA in nonobese subjects.Results: A total of 200 eligible patients with type 2 diabetes were studied (64.5% men; aged 60.1 ± 13.6 years; body mass index [BMI], 26.3 ± 5.2 kg/m2). When OSA was defined as apnea-hypopnea index ≥5/hour, its prevalence was 80.5%. The prevalence of OSA in subjects with a BMI <20 kg/m2, ≥20 and <25 kg/m2, ≥25 and <30 kg/m2, and ≥30 kg/m2 was 38.9%, 73.5%, 86.5%, and 97.5%, respectively. The severity of OSA increased in proportion to BMI, especially when the BMI was >25 kg/m2. The prevalence of OSA was also high (66.3%) in normal-weight subjects (BMI <25 kg/m2). Furthermore, the serum triglyceride level (OR, 1.01; 95% confidence interval, 1.00 to 1.02; P = .042) was significantly related to OSA.Conclusion: A high prevalence of OSA was observed in this nonobese population of Japanese patients with type 2 diabetes. The triglyceride level was associated with OSA among nonobese patients.Abbreviations: AHI = apnea-hypopnea Index; BMI = body mass index; CI = confidence interval; ESS = Epworth Sleepiness Scale; HbA1c = glycated hemoglobin; OR = odds ratio; OSA = obstructive sleep apnea; PAT = peripheral arterial tone; T2D = type 2 diabetes; TG = triglyceride |
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