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N-glycopeptide Signatures of IgA2 in Serum from Patients with Hepatitis B Virus-related Liver Diseases
Affiliation:3. Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, China;4. Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China;5. Beijing Advanced Innovation Center for Precision Medicine, Beihang University, Beijing 100083, China;6. Key Lab of Intelligent Information Processing of Chinese Academy of Sciences (CAS), Institute of Computing Technology, CAS, Beijing 100190, China;12. Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China;8. School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030;9. State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210046, China;10. Department of Chemistry, Fudan University, Shanghai 200433, China
Abstract:
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  • Highlights
    • 18O/16O labeling N-glycopeptide quantification for 40-kDa band in HCC and LC.
    • •MRM verification of aberrant N-glycopeptides in healthy-HBV-LC-HCC cascade.
    • •TPLTAN205ITK (H5N5S1F1) and (H5N4S2F1) of IgA2 change in liver diseases.
    • •Variation in two N-glycopeptides abundance not caused by protein concentration.
    Keywords:Glycoproteomics  Glycomics  Liver Disease  Biomarker: Diagnostic  Mass Spectrometry  40-kDa Band  Glycopeptide  HBV-Related Liver Diseases  IgA2  Mass Spectremetry
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