Insulin Induces Microtubule Stabilization and Regulates the Microtubule Plus-end Tracking Protein Network in Adipocytes
Affiliation:
3. From the 3Department of Cellular & Molecular Medicine,;4. 4Department of Medicine, Division of Endocrinology,;5. 5Department of Pharmacology,;6. 6Department of Chemistry & Biochemistry, University of Arizona College of Medicine, Tucson, Arizona 85721;
Abstract:
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Highlights
?Insulin Affects the Phosphorylation of G2L1, MARK2, CLIP2, EB1, AGAP3, and CKAP5.
?Insulin Increases CLASP2 +TIP Density and Decreases CLASP2 +TIP Velocity.
?Insulin Stimulates CLASP2 and G2L1 Trailing Along Microtubules.
?Insulin Stimulates α-Tubulin Acetylation at Lysine 40 and Microtubule Stabilization.
