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Identification of Candidate Plasma Protein Biomarkers for Cervical Cancer Using the Multiplex Proximity Extension Assay
Institution:4. 4OLINK Proteomics, Uppsala Science Park, SE-751 83, Uppsala, Sweden;;5. Department of Women′s and Children′s Health, 751 85, Uppsala University, Uppsala, Sweden;;6. Department of Radiation Sciences, Umeå University, SE-90187 Umeå, Sweden;;12. Department of Medical Biosciences, Clinical Chemistry, Umeå University, SE-90185 Umeå, Sweden
Abstract:
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  • Highlights
    • ?HPV is being introduced as the primary test in cervical cancer screening programs.
    • ?New biomarkers are needed for co-testing of women HPV positive in screening.
    • ?Analysis of plasma from women with invasive cervical cancer identified a 11-marker panel.
    • ?This signature shows high sensitivity and specificity to identify women with cancer.
    Keywords:Cancer biomarker(s)  Personalized medicine  Cervical cancer  Blood*  Clinical proteomics  Human Papillomavirus  Screening
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