Surface Loops in a Single SH2 Domain Are Capable of Encoding the Spectrum of Specificity of the SH2 Family,期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Surface Loops in a Single SH2 Domain Are Capable of Encoding the Spectrum of Specificity of the SH2 Family,

Institution:	3. Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi''an Jiaotong University, Xi''an 710049, China;;4. Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1;;5. Donnelly Centre for Cellular and Biomolecular Research, 160 College St., Toronto ON M5S 3E1, Canada

Abstract:	Download : Download high-res image (119KB) Download : Download full-size image Highlights •Surface loops play an essential role in SH2 domain specificity. •Diverse specificities may be obtained from a single SH2 domain by combinatorial mutations in the EF and BG loops. •The specificity of a loop mutant correlates with the sequence characteristics of the bait peptide used in its isolation.

Keywords:	Cancer Biology Chemoresistance Breast Cancer Mitochondria Function or Biology Stem Cells Autophagy NMR Clinical Proteomics Antibiotics Cancer Stem Cells Mitochondria NMR-metabolomic
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