The distribution of IGF2 and IMP3 in osteosarcoma and its relationship with angiogenesis |
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Authors: | Peng Chen Shao-jin Wang Hong-bo Wang Peng Ren Xi-qian Wang Wen-guang Liu Wan-li Gu Dong-qing Li Ting-guo Zhang Cheng-jun Zhou |
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Institution: | (1) Department of Pathology, The Second Hospital, Shandong University, 247#, BeiYuan Street, Jinan, Shandong, 250033, People’s Republic of China;(2) Department of Osteology, The Second Hospital, Shandong University, 247#, BeiYuan Street, Jinan, Shandong, 250033, People’s Republic of China;(3) Department of Pathology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong, 250012, People’s Republic of China |
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Abstract: | The aim of this study was to investigate the expression patterns of IGF2 and IMP3 in osteosarcoma as well as its relationship
with angiogenesis in the tumor. IGF2 and IMP3 expression was detected by immunohistochemical staining in the serial sections
of the osteosarcoma. The impacts of IGF2 and IMP3 expression patterns on tumor angiogenesis were evaluated by statistics.
The IGF2 and IMP3 staining had different expression patterns in different osteosarcoma. Twelve out of the sixty-four cases
of conventional osteosarcoma showed nuclear staining patterns, and twenty-nine showed cytoplasmic staining of IGF2 and IMP3
simultaneously. On the other hand, fourteen cases showed nuclear IGF2 staining but cytoplasmic IMP3 expression, and nine cases
showed nuclear IMP3 staining and cytoplasmic IGF2 expression. Twenty-eight out of forty-seven cases of parosteal osteosarcoma
showed nuclear IGF2 and IMP3 expression, nine showed cytoplasmic IGF2 and IMP3 expression simultaneously. Seven out of forty-seven
cases of parosteal osteosarcoma expressed IGF2 with nuclear staining but expressed IMP3 with cytoplasmic staining. Meanwhile,
three cases expressed IGF2 with cytoplasmic staining but expressed IMP3 with nuclear staining. Similar to the parosteal osteosarcoma,
the periosteal osteosarcoma expressed IGF2 and IMP3 mainly with nuclear staining simultaneously, forty out of fifty-five cases
of periosteal osteosarcoma did that. Five out of fifty-five cases expressed IGF2 and IMP3 with cytoplasmic staining at the
same time. Four cases showed nuclear IGF2 staining and cytoplasmic IMP3 staining. In the parosteal and periosteal osteosarcoma,
there was no significant difference in IGF and IMP3 expression patterns (P = 0.216). However, compared with conventional osteosarcoma, the parosteal and periosteal osteosarcoma showed significant
difference in IMP3 and IGF2 expression (P = 0.016, P = 0.023). IGF2 and IMP3 expression patterns were positive correlation in the different osteosarcoma (r = 0.1021, P = 0.032). The Microvessel density (MVD) in osteosarcoma with IGF2 and IMP3 cytoplasmic staining was more than that with nuclear
expression of IGF2 and IMP3, and the difference was significant (P = 0.024). Moreover, the conventional osteosarcoma with cytoplasmic IGF and IMP3 showed more MVD than parosteal and periosteal
osteosarcoma with cytoplasmic IGF and IMP3, and the difference was significant (P = 0.035). IGF2 and IMP3 had different expression patterns, which might be associated with angiogenesis. However, cytoplasmic
and nuclear expression of IGF2 and IMP3 might play different roles in the angiogenesis of osteosarcoma. |
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