| ~(125)Ⅰ—蜂毒肽在小鼠体内分布、吸收、排泄的研究 |
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| 引用本文： | 戴廷恩,顾承芝,钱锐.~(125)Ⅰ—蜂毒肽在小鼠体内分布、吸收、排泄的研究[J].动物学研究,1987,8(4):349-352. |
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| 作者姓名： | 戴廷恩 顾承芝 钱锐 |
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| 作者单位： | 成都军区昆明总医院同位素科
(戴廷恩，顾承芝)，中国科学院昆明动物研究所(钱锐) |
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| 摘 要： | 以氯胺T为氧化剂参照Hunter和Greenwood的多肽类化合物的碘化标记法,制备了~(125)I—标记的蜂毒肽在小鼠体内分布、吸收、排泄的研究,实验证明小鼠肌注~(125)I—蜂毒肽后,吸收很快,主要分布部位为肾、肺、心、肝、小肠、关节、脾与肌肉,脑组织中含量很少,肌肉注射后5分钟血液中含量可达70％,~(125)—I蜂毒肽主要经肾排泄,肌注后30分钟肾脏浓集最高,而尿液中以1.5小时为最高,而粪便中排泄少。
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| 关 键 词： | ~(125)—Ⅰ 蜂毒肽 小鼠 注射 体内分布 |
THE STUDY OF DISTRIBUTION, RESORPTION AND EXCRETION OF 125-IODINE LABELLED MELITTIN IN MOUSE |
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| Dai Tingen Gu Chengzhi.THE STUDY OF DISTRIBUTION, RESORPTION AND EXCRETION OF 125-IODINE LABELLED MELITTIN IN MOUSE[J].Zoological Research,1987,8(4):349-352. |
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| Authors: | Dai Tingen Gu Chengzhi |
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| Abstract: | After intramuscular injection of the iodine-125 labelled melittin the mouse can resorpt quickly. The main resorpted parts are blood, liver, kindey, joint, muscle, intestin, except resorpted level is about 70%.
The iodine-125 labelled melittin wildly distributed into whole organs of the body. Mainly gathered organes are kidney, lung, liver, blood, small intestine, joint, spleen, muscle. 5 or 15 minutes after injection, it appeared highly and decreased gradually in 4 hours, most parts disapeared in 24 hours.
The characteristic excretion of the iodine-125 labelled melittin is kidney, excretion, 30 minutes later the concentration reaches high. An hour and half hours the concentration is the highest in urine, very low in feces. |
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| Keywords: | 125 I-Iodine labelled melittin Mouse Inject |
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