| 骨髓单个核细胞在周围神经修复中的应用 |
| |
| 引用本文： | 陈琳,;黄红云,;敖强,;左焕琮,;张玉琪.骨髓单个核细胞在周围神经修复中的应用[J].中华细胞与干细胞杂志(电子版),2014(4):57-61. |
| |
| 作者姓名： | 陈琳 ;黄红云 ;敖强 ;左焕琮 ;张玉琪 |
| |
| 作者单位： | [1]清华大学医学中心,北京100084; [2]首都医科大学附属北京康复医院神经修复中心;,北京100084; [3]不详;,北京100084; [4]清华大学玉泉医院神经外科,北京100084; |
| |
| 摘 要： | 基础研究证实,多种细胞移植可以促进周围神经修复,其中来源丰富的骨髓单个核细胞,因具有取材过程简单、无交叉感染风险、无免疫排斥、可以自体移植等诸多优点,是目前重要的候选细胞之一。本文就近期有关骨髓单个核细胞的神经修复作用机制的研究、细胞植入修复受损周围神经的文献、以及与各种生物材料复合应用构建的组织工程化神经等方面最新进展进行综述,以期促进该领域基础向临床应用的转化。
|
| 关 键 词： | 骨髓 单核细胞 周围神经 损伤 细胞移植 导管 |
Role of bone marrow mononuclear cells in peripheral nerve repair |
| |
| Institution: | Chen Lin, Huang Hongyun, Ao Qiang, Zuo Huancong, Zhang Yuqi. (Tsinghua University Medical Center (Chen Lin, now Tsinghua University Yuquan Hospital). Beijing 100084, China) |
| |
| Abstract: | Preclinical researches have demonstrated that transplantation of many kinds of cells has a capability to promote the restoration of peripheral nerve injury. Of them, bone marrow mononuclear cells （BM-MNC） are an important candidate because of many advantages including rich source, easy and simple isolation, no infection risk, and no immune rejection. In order to encourage the clinical translational application from the basic researches, here, we review the latest studies of the action mechanism of bone marrow mononuclear cells for nerve repair, the most recent progress of the implant of BM-MNC to repair damaged peripheral nerve, as well as a variety of tissue-engineered nerve conduit built with the biological materials with BM-MNC. |
| |
| Keywords: | Bone marrow monocytes peripheral nerve injury cell transplantation |
| 本文献已被 维普 等数据库收录！ |
|
