A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells |
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| Authors: | Kim Kyung Noo Lee Jiyong Kim Dong Hoon Yoo Jong-Shin Kwon Ho Jeong |
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| Institution: | Chemical Genomics National Research Laboratory, Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea. |
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| Abstract: | Modified thymidine analogues have been highlighted as useful agents for the treatment of cancer and viral diseases due to their potent biological activities. In the present study, we synthesized a new thymidine analogue, 7-(3-bromo-phenoxy)-thymidine (4a), as a potential lead for anti-tumor agent. Compound 4a potently inhibits HeLa cell proliferation with an IC(50) of 15 microM. |
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