An improved sequence handling package that runs on the Apple Macintosh

We report improvements to our sequence analysis package andadaptation to run on the Apple Macintosh range of machines.The ‘standard’ version of the programs, which runon a VAX, has been given a new user interface that makes theprograms very much easier to work with and has facilitated themove to the Macintosh. The reorganization of the code shouldsimplify moves to other systems that offer WIMP user interfaces.In addition to a large number of small but useful extra features,some important new analytical functions have been devised. Theseinclude sequence and contig editors; optimal alignment and comparisonmethods; and a new method for comparing the observed and expectedfrequencies of selected oligonucleotides. Received on February 12, 1990; accepted on April 19, 1990