Serum mediated inhibition of cellular immunity to methylcholanthrene-induced murine sarcomas |
| |
| Authors: | I Hellstr?m K E Hellstr?m H O Sj?gren |
| |
| Affiliation: | 1. State Key Laboratory of Information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University, 129 Luoyu Road, Wuhan 430079, China;2. Collaborative Innovation Center for Geospatial Technology, 129 Luoyu Road, Wuhan 430079, China;1. Department of Mechanical Engineering, Faculty of Engineering, Beirut Arab University, Lebanon;2. Department of Mechanical Engineering, Faculty of Engineering, Alexandria University, Egypt |
| |
| Abstract: | The colony inhibition test was used to demonstrate cellular immunity to primary methylcholanthrene (MCA)-induced mouse and rat tumors. Serum from the tumor-bearing animals, obtained at the time of tumor removal and explantation into culture, abrogated the inhibitory effect of autochthonous lymph node cells (LNC). Serum taken before palpable tumors could be detected did not abrogate the inhibitory LNC effect. Lymph node cells from mice transplanted with MCA-induced tumors inhibited colony formation of the respective tumors, and serum from the same mice abrogated the LNC effect, even when harvested before the appearance of palpable tumors. Cellular immunity but no blocking effect with serum was seen in mice transplanted with MCA tumor cells that did not develop tumors. Splenectomized animals had less blocking activity in their serum than did their shamoperated controls. The blocking activity of serum from mice transplanted with MCA sarcomas decreased within 4 days following tumor removal. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
