Eukaryotic endonuclease VIII-Like proteins: New components of the base excision DNA repair system |
| |
Authors: | I R Grin D O Zharkov |
| |
Institution: | Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. |
| |
Abstract: | Base excision DNA repair is necessary for removal of damaged nucleobases from the genome and their replacement with normal
nucleobases. Base excision repair is initiated by DNA glycosylases, the enzymes that cleave the N-glycosidic bonds of damaged deoxynucleotides. Until recently, only eight DNA glycosylases with different substrate specificity
were known in human cells. In 2002, three new human DNA glycosylases (NEIL1, NEIL2, and NEIL3) were discovered, all homologous
to endonuclease VIII, a bacterial protein, which also participates in DNA repair. The role of these enzymes remains mostly
unknown. In this review we discuss recent data on the substrate specificity of the NEIL enzymes, their catalytic mechanism,
structure, interactions with other components of DNA repair system, and possible biological role in preventing diseases associated
with DNA damage. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|