New insights into the function of IAP proteins: modulation of the MYC/MAX/MAD network |
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| Authors: | Wright Casey W Duckett Colin S |
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| Affiliation: | Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA. |
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| Abstract: | A growing number of studies have revealed that the inhibitor of apoptosis (IAP) proteins play a variety of cellular roles in addition to suppression of apoptosis. A recent study in Molecular Cell demonstrates that one IAP member, c-IAP1, functions to potentiate the activity of Myc by triggering the ubiquitination and proteasomal degradation of the Myc inhibitory protein Mad1. |
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