Mutations Modulating Raf Signaling in Drosophila Eye Development |
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Authors: | B J Dickson A van-der-Straten M Dominguez and E Hafen |
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Institution: | Present address: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720. |
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Abstract: | The R7 fate is specified during Drosophila eye development by an inductive signal transduced intracellularly via the Raf kinase. We have performed a genetic screen for dominant mutations that alter the efficiency with which cells respond to a constitutively activated Raf kinase. Such mutations may affect genes involved in signal transduction downstream of Raf. We have isolated 44 mutations that define eight genes. One of these encodes a mitogen-activated protein kinase homologue; another is a putative target gene of this signaling pathway. We present the results of this screen in detail, as well as a preliminary genetic analysis of the six loci still to be characterized molecularly. |
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