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Platelet activity in immune lysis of Trypanosoma musculi |
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| Authors: | P Viens R Dubois PAL Kongshavn |
| Institution: | *Department of Microbiology and Immunology, Faculty of Medicine, Université de Montréal, P.B. 6128, Montreal, Quebec H3C 3J7, Canada ?Montreal General Hospital Research Institute and Department of Physiology, McGill University, Montreal, Quebec, Canada |
| Abstract: | It was observed that, when blood from CBA/J mice recovering from T. musculi infection was added to parasites in vitro, platelets adhered to the trypanosomes which subsequently died. This platelet adherence trypanosomal lysis (PATL) activity of the blood appeared late in infection and persisted long after parasites had been eliminated from the blood, although showing a cyclical pattern of activity. Trypanosomal lysis in vitro by fresh (non-heat-inactivated) immune plasma free of platelets could also be demonstrated. |
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