| 慢性常压缺氧和缺氧伴CO_2潴留大鼠红细胞变形能力与能量代谢的研究 |
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| 引用本文： | 杨晓静,钱桂生,毛宝龄. 慢性常压缺氧和缺氧伴CO_2潴留大鼠红细胞变形能力与能量代谢的研究[J]. 中国应用生理学杂志, 1995, 0(4) |
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| 作者姓名： | 杨晓静 钱桂生 毛宝龄 |
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| 作者单位： | 重庆第三军医大学新桥医院呼吸中心 |
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| 摘 要： | 本工作研究了慢性常压缺氧和缺氧伴ＣＯ＿２潴留肺动脉高压大鼠红细胞变形能力和红细胞内ＡＴＰ含量的变化。结果表明，慢性常压缺氧和缺氧伴ＣＯ＿２潴留大鼠不同切应力下的红细胞变形指数和红细胞内ＡＴＰ含量均明显低于其对照组，且该两组红细胞内ＡＴＰ含量与不同切应力下的红细胞变形指数呈显著正相关。提示慢性缺氧和伴ＣＯ＿２潴留大鼠红细胞内ＡＴＰ含量降低可能是导致红细胞变形能力降低的诸因素之一，后者又可导致和加重肺动脉高压的形成。
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| 关 键 词： | 缺氧，CO＿2潴留，肺动脉高压，红细胞变形能力，红细胞ATP |
STUDY ON ERYTHROCYTE DEFORMABILITY AND ENERGY METABOLISM IN RATS DURING CHRONICSOBARIC HYPOXIA AND CO_2 RETENTION |
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| Yang Xiaojing,Qian Guisheng,Mao Baoling. STUDY ON ERYTHROCYTE DEFORMABILITY AND ENERGY METABOLISM IN RATS DURING CHRONICSOBARIC HYPOXIA AND CO_2 RETENTION[J]. Chinese journal of applied physiology, 1995, 0(4) |
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| Authors: | Yang Xiaojing Qian Guisheng Mao Baoling |
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| Abstract: | The changes of erythrocyte deformability and erythrocyte ATP were studied in 14 chromicisobaric hypoxic rats,14 hypoxic rats with CO_2 retention and 10 normal rats. The results dem-onstrated that the erythrocyte deformation index and the contents of erythrocyte ATP weresignificantly lower in chronic isobaric hypoxic rats and hypoxic rats with CO_2 retention thanthose in the normal rats.The erythrocyte deformability in chronic isobaric hypoxic rats andhypoxic rats with CO_2 retention were positively correlated to the contents of erythrocyte ATP. These findings suggest that decrease in erythocyte ATP may be one of the factors causing de-crease in erythrocyte deformability in rats during chronic isobaric hypoxia and CO_2 retention.The latter will result in and aggravate pulmonary hypertension. |
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| Keywords: | hypoxia CO_2 retention erythrocyte defomability erythrocyte ATP |
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