Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex |
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| Authors: | Shuzhang Yang Kai Wang Otto Valladares Sridhar Hannenhalli Maja Bucan |
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| Affiliation: | (1) Department of Genetics and Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA |
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| Abstract: | Background The prefrontal cortex is important in regulating sleep and mood. Diurnally regulated genes in the prefrontal cortex may be controlled by the circadian system, by sleep:wake states, or by cellular metabolism or environmental responses. Bioinformatics analysis of these genes will provide insights into a wide-range of pathways that are involved in the pathophysiology of sleep disorders and psychiatric disorders with sleep disturbances. |
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