Conformational transitions and hydration of poly d (A-T) · poly d (A-T) in fibers |
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Authors: | A Abouelkassimi G Albiser S Premilat |
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Institution: | (1) UA CNRS 494, Université de Nancy I, Faculté des Sciences, Laboratoire de Biophysique Moléculaire, BP 239, F-54506 Vandoeuvre Les Nancy, France |
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Abstract: | Conformational transitions of poly d(A-T) · poly d (A-T) have been studied by fiber X-ray diffraction and measurement of fiber dimensions. Results obtained for the D-A-B and D-B transitions are presented and analyzed. For all these form transitions, cooperativity effects are observed for the variation of the rise per nucleotide versus the relative humidity. Detailed information about hydration of the polynucleotide during form transitions and the numbers of water molecules per nucleotide necessary to stabilize the different helical conformations are presented.
Offprint requests to: S. Premilat |
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Keywords: | poly d(A-T) · poly d(A-T) D-A-B and D-B helical transitions DNA hydration X-ray fiber diffraction |
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