Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans |
| |
Authors: | Carrillo Romen León Leticia G Martín Tomás Martín Víctor S Padrón José M |
| |
Affiliation: | Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain. |
| |
Abstract: | In this study, we synthesized a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans with diverse functional groups. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show the relevance for antiproliferative activity of the alpha,beta-unsaturated ester side chain at position 2 of the THP ring. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|