Expression of nodal signalling components in cycling human endometrium and in endometrial cancer |
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| Authors: | Irene Papageorgiou Peter K Nicholls Fang Wang Martin Lackmann Yogeshwar Makanji Lois A Salamonsen David M Robertson Craig A Harrison |
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| Institution: | (1) Prince Henry's Institute of Medical Research, 246 Clayton Road, Clayton, Vic, 3168, Australia;(2) Department of Obstetrics and Gynecology, Monash University, Clayton, Vic, 3168, Australia;(3) Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic, Australia |
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| Abstract: | Background The human endometrium is unique in its capacity to remodel constantly throughout adult reproductive life. Although the processes
of tissue damage and breakdown in the endometrium have been well studied, little is known of how endometrial regeneration
is achieved after menstruation. Nodal, a member of the transforming growth factor-beta superfamily, regulates the processes
of pattern formation and differentiation that occur during early embryo development. |
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