A new prostaglandin E1 analogue (CL-115,574) II. Effects on gastric acid secretion in the dog |
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| Authors: | Donald E Wilson MD William Scruggs BS Jay E Birnbaum PhD |
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| Institution: | 1. The Department of Medicine, Section of Gastroenterology University of Illinois at the Medical Center Chicago, Illinois, USA;2. Medical Research Division, American Cynamid Company Lederle Laboratories, Pearl River, New York, USA |
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| Abstract: | The efficacy of CL-115,574, a prostaglandin E1 analogue, as an acid antisecretory agent was evaluated in dogs. CL-115,574 inhibited acid secretion maximally at an oral dose of 20 μg/kg causing 100% inhibition of acid secretion up to one hour after administration, with significant inhibition of secretion (30%) still present nearly four hours after drug administration. The wide disparity between the maximally effective antisecretory dose 20 μg/kg and the dose at which reproducible side effects occurred (1 mg/kg) suggests that this compound may be developed as an antisecretory compound for use in man. |
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