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4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs |
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| Authors: | Manetti Dina Martini Elisabetta Ghelardini Carla Dei Silvia Galeotti Nicoletta Guandalini Luca Romanelli Maria Novella Scapecchi Serena Teodori Elisabetta Bartolini Alessandro Gualtieri Fulvio |
| Institution: | Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via G. Capponi 9, I-50121, Firenze, Italy. |
| Abstract: | Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. |
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