Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases |
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| Authors: | Lee J Kang S U Kim S Y Kim S E Kang M K Jo Y J Kim S |
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| Affiliation: | Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Kwanak-Ku, South Korea. jeewoo@snu.ac.kr |
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| Abstract: | The structure activity relationship on a series of ester and hydroxamate analogues of methionyl and isoleucyl adenylate has been investigated through introducing linkers between the 1'-position of ribose and adenine surrogates as methionyl-tRNA, and isoleucyl-tRNA synthetase inhibitors, respectively. The results indicate that ester analogue 23 was found to be a potent inhibitor of Escherichia coli methionyl-tRNA synthetase, and its interaction with the active site was proposed by a molecular modeling study. |
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