大鼠胎儿期噪声暴露对成年后听觉目标探索行为的影响

环境噪声被认为是影响健康的重要因素之一,但有关胎儿期环境噪声对成年后听觉行为的影响缺少系统的研究。本研究对胎儿噪声暴露组、成年噪声暴露组和正常对照组大鼠在出生后第11周开始进行为期17d的听觉目标探索训练,观察其在水迷宫中寻找听觉目标的行为差异。以大鼠寻找平台的时间、成功率、运动轨迹为指标对其听觉目标探索行为进行比较。结果发现,噪声暴露可导致大鼠在水迷宫中的听觉目标探索行为的缺陷,在胎儿期噪声暴露比成年期噪声暴露对动物探索听觉目标的行为影响更大。该结果提示,孕期进行适当的噪声防护以保证优生优育是非常必要的。

Influence of Prenatal Noise Exposure on the Auditory Object Exploration Behavior of Adult Rats

Environmental noise has been considered as one of the important factors to influence health,however,few studies have been conducted regarding the prenatal noise exposure on the auditory behavior of adult.The present study compares the auditory object exploration behavior determined in water maze apparatus among three different groups of rats,i.e.,prenatal noise exposure group,adult noise exposure group,and normal control group.Rats were trained to perform auditory object exploration task from the 11th week after birth and the test lasted for 17 consecutive days.The auditory object exploration behavior of the three groups of rats was compared by the following indexes:the latency and the rate of success for finding the platform,as well as the category of movement tracks.The results indicate that noise exposure can deficit the auditory object exploration behavior of rats,and noise exposure during prenatal period has stronger influence on the adult auditory behavior than noise exposure during adult period does.The results suggest that it is necessary for human and animals to be away from hazardous noise during pregnancy.