Copper(II) complexes of the beta-blocker pindolol: properties, structure, biological activity |
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| Authors: | Panayot R. Bontchev Ivayla N. Pantcheva Ranko P. Bontchev Darvin S. Ivanov Nikolay D. Danchev |
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| Affiliation: | (1) Faculty of Chemistry, Sofia University, Sofia, Bulgaria;(2) University of Houston, Texas, USA;(3) Faculty of Pharmacy, Medical University Sofia, Bulgaria |
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| Abstract: | The complex formation between copper(II) and the antihypertensive drug pindolol (HPin) was studied both in aqueous and methanolic media. Two complexes are formed at different metal-to-ligand molar ratios. The mononuclear complex Cu(Pin)2(HPin)2 contains two ligands in an anionic bidentate form and two - in a neutral form bound monodentately. The second complex Cu2Pin2Cl2 is dinuclear and its structure was determined by X-ray diffraction. The compound crystallizes in the monoclinic group C2/c with cell components a = 14.4998(13)Å, b = 18.511(2)Å, c = 14.2982(13)Å,  =90 °,  =109.556(2)°,  =90 ° and Z = 12 at 293K. A pharmacological study on the influence of pindolol and its mononuclear complex on the heart rate of rats was performed. The complex is more active and has a longer effect in comparison with the pure non-coordinated pindolol in equitoxic doses. |
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| Keywords: | aminoalcohols Cu(II) complexes toxicological and pharmacological activity X-ray structure |
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