Gel electrophoresis of partially purified cytochromes P450 from liver microsomes of variously-treated rats

Liver microsomes and partially purified cytochromes P₄₅₀ prepared from untreated animals or those injected with phenobarbital, or 3-methylcholanthrene, or polychlorinated biphenyls, were subjected to slab-gel SDS-electrophoresis. There were observed marked differences, after these treatments, in the gel-electrophoresis patterns of the induced cytochromes P₄₅₀ in the microsomes and partially purified preparations.