Biological effectiveness of ionizing radiations of various quality in Escherichia coli bacteria (a theoretical analysis). Cell radiosensitivity and DNA repair

On the basis of the ideas reported earlier a study was made of the dependence of radiosensitivity (D0-1) of isogenic mutations of E. coli upon LET. This dependence was shown to be conditioned not only by the physical parameters of radiation but also by the ability of cells to repair definite types of DNA lesions. The influence of the balance in the activity of repair enzymes in E. coli on the shape of D0-1 (LET) curve is discussed.