Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe |
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| Authors: | X Le Goff A Woollard and V Simanis |
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| Institution: | (1) Cell Cycle Control Laboratory Swiss Institute for Experimental Cancer Research (ISREC) Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland e-mail: viesturs.simanis@isrec.unil.ch Tel.: +41-21-6925888, Fax: +41-21-6526933, CH;(2) ICRF Cell Cycle Control Laboratory PO Box 123, London WC2A 3PX, UK, GB;(3) MRC Laboratory of Molecular Biology Cell Biology Division, Hills Road Cambridge CB2 2QH, UK, GB |
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| Abstract: | The fission yeast gene cps1, which encodes the catalytic subunit of β-glucan synthase, was isolated in a screen for mutants that show an increase in ploidy at the restrictive temperature. cps1 mutants display defects in both polarity and septation at the permissive temperature, and become swollen and multinucleate
at the restrictive temperature. Analysis of the interaction of cps1 with other mutations suggests the existence of a septation checkpoint, which requires the activity of the protein kinase
wee1 for function.
Received: 14 February 1999 / Accepted: 11 May 1999 |
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| Keywords: | 1 3-β -D-Glucan synthase Cell cycle Actin Cytokinesis Mitosis |
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