Effects of ubiquinones on spontaneous membrane hyperpolarizations in a cloned monkey kidney cell line |
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| Authors: | N Yamashita H Chang K Kurokawa E Ogata |
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| Affiliation: | 15. Department of Biology, University of Louisiana at Lafayette, Lafayette, LA, 70503, USA;1. Institute of Radiation Medicine, Fudan University, Xietu Road 2094, Shanghai 200032, China;2. Guangdong Provincial Key Laboratory of Biomedical Imaging, Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, China |
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| Abstract: | The effects of ubiquinones on spontaneous membrane hyperpolarizations in JTC-12 cells were examined. There were three types of spontaneous hyperpolarizations; rhythmic, sporadic and oscillatory types. The oscillatory type was not observed in the standard medium, whereas it was observed in sodium-free medium or in the medium containing 300 nM coenzyme Q10. The number of the cells showing spontaneous hyperpolarizations significantly increased in the medium containing coenzyme Q10 (47.7%) as compared to the control (18.9%). However, coenzyme Q1 (500 nM) showed no effects. |
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