Calibration and assessment of channel-specific biases in microarray data with extended dynamical range |
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| Authors: | Henrik Bengtsson G?ran J?nsson and Johan Vallon-Christersson |
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| Institution: | (1) Mathematical Statistics, Centre for Mathematical Sciences, Lund University, Box 118, SE-221 00 Lund, Sweden;(2) Department of Oncology, Lund University, Barngatan 2, SE-221 85 Lund, Sweden |
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| Abstract: | Background Non-linearities in observed log-ratios of gene expressions, also known as intensity dependent log-ratios, can often be accounted
for by global biases in the two channels being compared. Any step in a microarray process may introduce such offsets and in
this article we study the biases introduced by the microarray scanner and the image analysis software. |
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