Inhibition of aspartic proteinases by alpha 2-macroglobulin. |
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| Authors: | D J Thomas A D Richards and J Kay |
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| Institution: | Department of Biochemistry, University of Wales College of Cardiff, U.K. |
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| Abstract: | The effect of alpha 2-macroglobulin, one of the major antiproteinases in the plasma of vertebrates, on the action of the aspartic proteinases chymosin, cathepsin D and cathepsin E towards peptide and protein substrates at pH 6.2 was examined. Activities towards protein substrates were blocked, thus demonstrating that alpha 2-macroglobulin can inhibit aspartic proteinases, in addition to serine proteinases, cysteine proteinases and metalloproteinases. |
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