Molecular mechanisms of nickel carcinogenesis |
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| Authors: | Costa Max |
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| Institution: | Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA. |
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| Abstract: | A brief review of the molecular mechanisms of nickel carcinogenesis is presented. Molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of nickel-induced gene silencing by DNA hypermethylation in mammalian cells and by its ability to inhibit histone acetylation. Model systems designed to study the molecular mechanism of gene silencing are discussed. |
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